Overview
Clinical Meaning
Hypoxic Ischemic Encephalopathy occurs in two phases.
WHNP
WHNP
Hypoxic-Ischemic Encephalopathy occurs in two phases. Primary injury: ATP depletion leads to failure of Na/K ATPase, intracellular calcium influx, and excitotoxic glutamate release. Latent period (6-hour therapeutic window): partial energy recovery. Secondary injury: mitochondrial failure, ROS production, inflammation (IL-1beta, TNF-alpha), and apoptosis via caspase activation. Therapeutic hypothermia (33.5C for 72 hours) reduces metabolic rate by 5% per degree, decreases excitotoxicity, and inhibits apoptotic pathways.
Unlock full lesson + practice questions
4 more sections with scenarios, priorities, and review drills.
Final rapid review before practice
Next study step
Finish the lesson first, then choose a focused activity to apply what you just reviewed.
Continue studying
Sign in to save progress on this lesson.
Unlock the interactive lesson quiz with a plan that includes this WHNP pathway. You can still explore topic-filtered questions from the bank hubs below.