Overview
Clinical Meaning
Ulcerative colitis involves continuous mucosal inflammation starting at the rectum and extending proximally.
WHNP
WHNP
Ulcerative colitis involves continuous mucosal inflammation starting at the rectum and extending proximally. Driven by Th2 cytokine response (IL-5, IL-13) with neutrophilic crypt abscesses. Always involves rectum (vs Crohn which can skip). 5-ASA (mesalamine) is first-line for mild-moderate disease. Biologics (infliximab, vedolizumab) for moderate-severe. Increased colorectal cancer risk after 8-10 years requiring surveillance colonoscopy.
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